Service

Toprion Bio’s Clinical Pathology Laboratory is equipped with comprehensive and advanced testing instruments, all of which have undergone systematic validation. We provide a full suite of clinical pathology services to support clients in animal model establishment, preclinical research, and clinical studies. Our clinical pathology scientists possess extensive expertise in animal and human hematology, coagulation, serum […]

Toprion Bio has established partnerships with renowned ophthalmic hospitals in Beijing, Shanghai and other regions. We are capable of conducting safety and efficacy evaluations of ophthalmic therapeutic drugs or implantable devices, as well as assessing ocular effects induced by drugs administered via other routes (such as oral administration). We can perform studies under GLP conditions,

Toprion Bio offers testing services for drug toxicity, mutagenicity, clastogenicity and morphological transformation activities using a comprehensive panel of test systems. In addition to conducting standalone genetic toxicology assays, our highly skilled technical staff and advanced laboratory equipment enable us to deliver a full package of genetic toxicology services, as well as customized comprehensive study

Toprion Bio boasts a highly skilled and experienced safety pharmacology evaluation team, capable of providing clients with comprehensive safety pharmacology evaluation services. All study designs comply with international guidelines for preclinical safety evaluation of new drugs, including ICH (S7A, S7B), CFDA regulations, and laboratory animal care and use guidelines. Service Scope: Cardiovascular System Safety Pharmacology

Supported by other departments including Test Article Formulation and Analysis, Toxicokinetics and Bioanalysis, Immunology, and Pathology, the General Toxicology Department is capable of performing a full range of toxicological evaluations. With the increasing diversity of small molecules and biopharmaceuticals, there is a growing demand for increasingly complex toxicology study programs and comprehensive design and consideration

We apply a variety of computational tools and resources to help research teams solve key challenges in new drug R&D, such as biological activity, selectivity, and metabolic stability. Structure-Based Drug Design Ligand-Based Drug Design Calculation of Drug Metabolism and Physicochemical Properties Service Content 1: Protein 3D Structure Modeling – Homology Modeling or De Novo Modeling

The Structural Biology team at Toprion Bio provides customers with services including protein expression, purification and crystallization, as well as structural determination and analysis of biological macromolecules. Services include: Protein Crystallography Services Determination of the complete three‑dimensional structure of proteins and their complex assemblies provides the scientific basis for studying the structure‑function relationships of molecules

Toprion Bio has extensive and in-depth experience in the field of in vitro biology. Through enzyme-based assays, cell-based assays, cell biology, biochemistry, in vitro isotope detection, stable cell line establishment, RNAi and microRNA technologies, etc., we provide a complete set of biological services. Our capabilities cover GPCRs, kinases, nuclear hormone receptors, metabolic enzymes, epigenetic enzymes,

The In Vivo Pharmacology Department primarily provides clients with in vivo pharmacology services and services using in vivo materials. Its disease areas mainly cover oncology, metabolism, inflammation, central nervous system (CNS) diseases, etc. It has accumulated rich experience in the establishment of disease models, pharmacodynamic evaluation and screening, PD/PK and MOA experiments, etc. Collaborating with

In vitro biology provides professional support for drug discovery and development. Targeting has an advanced screening platform and offers multi-level and comprehensive services for partners. The business scope covers target validation, hit compound discovery, transition from hit compounds to lead compounds, optimization of lead compounds, and selection of clinical candidate compounds. With rich experience and