Muridda boasts a highly skilled and experienced safety pharmacology evaluation team, capable of providing clients with comprehensive safety pharmacology evaluation services. All study designs comply with international guidelines for preclinical safety evaluation of new drugs, including ICH (S7A, S7B), CFDA regulations, and laboratory animal care and use guidelines.
Service Scope:
Cardiovascular System Safety Pharmacology Studies
- Conscious unrestrained animals (cynomolgus monkeys, Beagle dogs, minipigs), with detection indicators including ECG, blood pressure monitoring, body temperature and motor activity
- Animals (cynomolgus monkeys, Beagle dogs), with detection indicators including ECG and blood pressure monitoring
- Langendorff isolated heart perfusion, with detection indicators including ECG, left ventricular systolic and diastolic pressure
- Purkinje fibers, recording of cardiac papillary muscle action potentials
- Patch clamp, hERG current recording
Respiratory System Safety Pharmacology Studies
- Conscious unrestrained animals (cynomolgus monkeys, Beagle dogs, minipigs), with detection indicators including respiratory rate and tidal volume
- Animals (cynomolgus monkeys, Beagle dogs), with detection indicators including respiratory rate and tidal volume
Central Nervous System Safety Evaluation
- Rats (FOB, Functional Observational Battery)
- Video analysis of spontaneous activity in rats and mice
- Rotarod fatigue test
- Threshold hypnosis test
- Grip strength test
- Body temperature measurement
Gastrointestinal System Safety Pharmacology Study:
Detection of gastrointestinal motility in mice
Urinary System Renal Function Safety Pharmacology Study:
Detection of renal function in rats
Muridda provides clients with safety evaluation services including general toxicology, safety pharmacology, reproductive and developmental toxicity, genetic toxicology, immunotoxicology, as well as pharmacokinetics and toxicokinetics, covering the entire process from drug discovery to IND and NDA submissions. Through cost-effective and efficient services, we help clients shorten experimental duration and reduce the cost of new drug research and development.
We have a professional team and practical experience in drug safety evaluation, capable of delivering high-quality data and rapid turnaround times to support various drug safety evaluation research. Toxicological studies are conducted in different animal species, and all procedures from dose design, experimental research to histology, pathology and clinical testing can be performed in accordance with non-GLP or GLP standards.