The Medicinal Chemistry Team at Toprion Bio is responsible for target identification (HI), lead generation (LG), and lead optimization (LO) projects for partners, and provides customers with the following services:
- Feasibility assessment of novel drug targets
- Scaffold design for target compound discovery
- Preliminary intellectual property analysis of newly designed scaffolds
- High-throughput screening and structure-based design of active compounds
- Discovery of active compounds to leads
- Library synthesis for lead generation (LG) and lead optimization (LO)
- Lead optimization to identification of preclinical candidates
- Structure-activity relationship (SAR) analysis using in vitro and in vivo data
- Computer-aided drug design and diversity analysis
- Structure-activity relationship (SAR) studies
- Non-GMP scale-up to support in vivo efficacy and toxicity studies
- Preparation for patent application
- Recommendation of appropriate DMPK and in vitro toxicology studies to support advancement of key compounds
- Project management
Scope of Services
Drug screening services, novel drug R&D services, lead optimization, target screening, selection of preclinical candidates, etc.
Drug Screening Service Process
- Submit drug screening requirements: including sample type, basic properties, requirements for assay systems or cell lines, target selection, project timeline, acceptance criteria, and other screening-related requirements.
- Submit to the Drug Screening Center for comprehensive evaluation: submit the above requirements in the form of a project task sheet. Internal evaluation will be conducted based on assay system, workload, estimated timeline, associated costs, and other indicators. Supplementary materials will be requested if needed.
- Discuss project details: negotiate on subsequent R&D and other project-related matters according to mutual requirements.
- Finalize experimental protocol and sign contract/agreement: once the final protocol is confirmed, a binding cooperation agreement or contract will be signed in accordance with procedures.
- Execute project and summarize results in experimental report: complete the project on time as agreed, summarize experimental data and conclusions, and issue an official experimental report stamped with the official seal of the center or legal entity.
- Accept results and complete cooperation: both parties conduct acceptance, sign off, and finalize the cooperation.