The Structural Biology team at Muruida provides customers with services including protein expression, purification and crystallization, as well as structural determination and analysis of biological macromolecules.
Services include:
- Protein expression and purification for crystallization
- Protein crystallization for novel or published targets
- Structural determination and analysis for novel or published targets
- Determination of protein‑compound complex structures by soaking or co‑crystallization
Protein Crystallography Services
Determination of the complete three‑dimensional structure of proteins and their complex assemblies provides the scientific basis for studying the structure‑function relationships of molecules in life activities and revealing the physicochemical nature of biological phenomena.
X‑ray diffraction of protein and protein‑complex crystals is one of the main methods for studying the detailed three‑dimensional structures of biological macromolecules.
Interpenetrating with other disciplines, and strongly driven by cutting‑edge fields such as structural genomics, protein crystallography has expanded from determining simple three‑dimensional protein structures to solving structures of various biological macromolecules and complexes, with increasing focus on the relationship between structure and function.
In pharmaceutical R&D, protein crystallography structures are widely used in structure‑based drug design and have become an important tool for new drug development.
Service Items:
- High‑throughput screening of protein crystallization conditions
- Protein diffraction data collection via synchrotron radiation
- Protein‑compound co‑crystallization; fragment screening
- Protein crystal structure determination and analysis
Recombinant Protein Expression and Purification
Muruida offers customers a variety of recombinant protein expression systems, with flexible options based on cost, timeline, advantages and limitations to meet diverse research needs.
We provide a full technical system from project design, gene optimization and expression condition optimization to purification, aiming to improve the expression level of your target protein.
Various protein expression systems are available: