Muruid has extensive and in-depth experience in the field of in vitro biology. Through enzyme-based assays, cell-based assays, cell biology, biochemistry, in vitro isotope detection, stable cell line establishment, RNAi and microRNA technologies, etc., we provide a complete set of biological services. Our capabilities cover GPCRs, kinases, nuclear hormone receptors, metabolic enzymes, epigenetic enzymes, ligand-gated ion channels, transporters, and more.
With advanced technologies and platforms, we support clients across a variety of major disease areas, including oncology, immuno-oncology, metabolic diseases, immune and inflammatory diseases, and neurological diseases. We provide multi-level and comprehensive services covering drug target validation, hit compound discovery, hit-to-lead transition, lead compound optimization, and selection of preclinical candidate compounds, striving to efficiently advance the R&D process for our clients.
Technical Approaches
Molecular biology, enzymology, cytology, immunology, organ and tissue testing, animal testing, immunoassays (ELISA), LC-MS/MS, HPLC, isotope labeling, bioassays
Service Areas
Cardiovascular diseases, cerebrovascular diseases, inflammatory and autoimmune diseases, metabolic diseases, musculoskeletal diseases, neurological and psychiatric disorders, oncology, nephropathy, hematological diseases, coagulation and hemostasis, ophthalmic models, vaccines, small molecule compounds, biomacromolecules, traditional Chinese medicines, cell therapy products, gene therapy products
Technology Platforms
Fluorescence Assays
Lance; Alphascreen; Z’-LYTE; HTRF, TR-FRET, FP, etc.
Luminescence Assays
Kinase-Glo; ADP-Glo, etc.
Absorbance Assays
UV; VI
Label-Free Screening Methods
SPR (Biacore) / ITC
Cell-Based Analysis
- Cell cytotoxicity detection
- Cell apoptosis detection and analysis
- Cell migration analysis
- Cell invasion analysis
- HTRF cell-based detection and analysis
- Immunostaining analysis
- Immunofluorescence analysis (96/384-well plates)
- Reporter gene assay (GFP / luciferase)
- Radioligand receptor binding assay
- Cellular uptake analysis
- Gene knockout analysis
- RNA interference
- microRNA overexpression analysis
- microRNA knockout analysis
- Application analysis of adenovirus / retrovirus / lentivirus vectors
Western Blot analysis
Cell migration assay
- Radioisotope Analysis
- Technology Platform (³H, ³³P, ³²P, ³⁵S, ¹²⁵I, ¹⁴C)
- Radioreceptor binding assay
- Radioligand binding assay
- Radioactive uptake assay
- Cell growth assay
- Radioimmunoassay (RIA)
- Immunoradiometric assay (IRMA)